Phosphoinositide 3-kinase in immunological systems Review uri icon

Overview

MeSH Major

  • Immune System
  • Phosphatidylinositol 3-Kinases
  • Signal Transduction

abstract

  • Phosphoinositide 3-kinases (PI3Ks) are an evolutionarily conserved family of signal transducing enzymes. A great variety of stimuli activate PI3K, leading to the transient accumulation of its lipid products in cell membranes. These lipids serve as second messengers to regulate the location and activity of an array of downstream effector molecules. In cells of the mammalian immune system, PI3K is activated by receptors for antigen, cytokines, costimulatory molecules, immunoglobulins and chemoattractants. Signaling via PI3K regulates immune cell proliferation, survival, differentiation, chemotaxis, phagocytosis, degranulation, and respiratory burst. Here we review our current understanding of PI3K signaling in leukocytes.

publication date

  • April 6, 2002

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1006/smim.2001.0337

PubMed ID

  • 11884226

Additional Document Info

start page

  • 7

end page

  • 18

volume

  • 14

number

  • 1