Double-blind switch study of imipramine or sertraline treatment of antidepressant-resistant chronic depression Academic Article uri icon

Overview

MeSH Major

  • Depressive Disorder, Major
  • Dysthymic Disorder
  • Imipramine
  • Sertraline

abstract

  • More than 50% of chronically depressed antidepressant nonresponders benefited from a switch from imipramine to sertraline, or vice versa, despite a high degree of chronicity. As in the initial trial, sertraline was generally better tolerated than imipramine. Switching to a standard antidepressant of a different class is a useful treatment strategy for antidepressant nonresponders and could be considered a standard of comparison for future studies of novel alternate strategies.

publication date

  • March 20, 2002

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 11879161

Additional Document Info

start page

  • 233

end page

  • 9

volume

  • 59

number

  • 3