New therapeutics for chronic heart failure Review uri icon

Overview

MeSH Major

  • Cardiovascular Agents
  • Heart Failure

abstract

  • Traditionally, clinicians have viewed heart failure either as a problem of excessive salt and water retention caused by abnormalities of renal blood flow, or as a hemodynamic problem associated with a reduced cardiac output and excessive peripheral vasoconstriction. Recently, clinicians have begun to adopt a neurohormonal model in which heart failure progresses because of the toxic effects of endogenous biological systems that become activated in heart failure. We review the rationale for existing heart failure therapies and discuss the reasoning behind the development of some emerging therapies.

publication date

  • March 9, 2002

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1146/annurev.med.53.082901.104004

PubMed ID

  • 11818463

Additional Document Info

start page

  • 59

end page

  • 74

volume

  • 53