Assessing the predictive value of clinical complete response to neoadjuvant therapy for rectal cancer: An analysis of 488 patients Academic Article Article uri icon


MeSH Major

  • Adenomatous Polyposis Coli
  • Colorectal Neoplasms
  • Colorectal Neoplasms, Hereditary Nonpolyposis
  • Liver Neoplasms
  • Neoplasm Metastasis


  • Clinical complete response to preoperative therapy as determined by preoperative digital rectal examination and proctoscopy or EUA is not an accurate predictor of pathologic complete response. A significant percentage of clinical complete responders have persistent deep tumors or nodal involvement. We do not recommend making treatment decisions based solely on the absence of clinically palpable or visible tumor after chemoradiation. Our data suggest that all acceptable-risk patients with a diagnosis of primary rectal cancer should undergo resection, regardless of their response to preoperative therapy.

publication date

  • February 12, 2002



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/S1072-7515(01)01159-0

PubMed ID

  • 11848629

Additional Document Info

start page

  • 131

end page

  • 5; discussion 135-6


  • 194


  • 2