Synthesis and characterization of 99mTc- and 188Re-complexes with a diamido-dihydroxymethylenephosphine-based bifunctional chelating agent (N2P2-BFCA) Academic Article uri icon

Overview

MeSH Major

  • Global Health
  • Internship and Residency
  • Ophthalmology

abstract

  • A diamido-dihydroxymethylenephosphine (N(2)P(2)) bifunction chelating agent (BFCA) was shown to form well-defined (99m)Tc- and (188)Re-chelate structures. The 4, 4-bis [bis-hydroxymethyl-phosphonyl-propylcarbonmoyl]-butyric acid bifunctional chelating agent (N(2)P(2)-BFCA) formed stable complexes with (99m)Tc and (188)Re in >95% yield with high radiochemical purity (RCP). The biodistribution of the (99m)Tc- and (188)Re-N(2)P(2)-BFCAs after intravenous injection studied in normal mice showed the activity was excreted primarily via renal-urinary pathway indicating their use for labeling peptides with (99m)Tc and (188)Re.

publication date

  • February 5, 2002

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0969-8051(01)00280-3

Additional Document Info

start page

  • 83

end page

  • 9

volume

  • 29

number

  • 1