Immunochromatographic strip-test detection of anti-K39 antibody in Indian visceral leishmaniasis Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Protozoan
  • Antigens, Protozoan
  • Leishmania
  • Leishmaniasis, Visceral
  • Protozoan Proteins

abstract

  • Stored sera from 429 Indian subjects were assayed to extend the analysis of the accuracy of immunochromatographic strip-test detection of anti-K39 antibody in the non-invasive diagnosis of visceral leishmaniasis (VL). All 225 samples from patients with proven Leishmania infection tested positive [estimated sensitivity = 100%; 95% confidence interval (CI)=98%-100%]. Sera from 99 of the 100 symptomatic patients with other diseases were non-reactive (estimated specificity = 99%; CI = 94%-100%). However, samples from 13 of the 104 apparently healthy controls showed positive strip-test results (estimated specificity = 88%; CI = 79%-93%), yielding an overall specificity of 93% (190/204; CI = 88%-96%). If applied in a practical clinical setting (on symptomatic patients in whom active VL is suspected and other common infections have been excluded), strip testing of serum for anti-K39 antibody should be both sensitive and specific for diagnosing VL in India.

publication date

  • April 29, 2002

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1179/000349802125000466

PubMed ID

  • 11989529

Additional Document Info

start page

  • 19

end page

  • 23

volume

  • 96

number

  • 1