High P-glycoprotein-mediated export observed in patients with a history of idiopathic thrombocytopenic purpura Academic Article Article uri icon

Overview

MeSH Major

  • Asthma

abstract

  • Studies have suggested that high P-glycoprotein expression in lymphocytes from patients with autoimmune disorders may affect disease outcome. Idiopathic thrombocytopenic purpura (ITP) and Evans' syndrome are widely thought to be autoimmune processes, however, the precise mechanisms remain unknown. Peripheral blood mononuclear cells from patients with refractory or recurrent ITP or Evans' syndrome were studied using the rhodamine 123 flow cytometric assay to investigate functional export levels. Lymphocytes from ITP and Evans' syndrome patients showed a significantly decreased ability to retain rhodamine, suggesting increased export protein function. Reverse transcription polymerase chain reaction distinguished P-glycoprotein as the likely export protein.

publication date

  • September 23, 2002

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1046/j.1365-2141.2002.03709.x

PubMed ID

  • 12181055

Additional Document Info

start page

  • 836

end page

  • 8

volume

  • 118

number

  • 3