Antitumor activity and prolonged expression from a TRAIL-expressing adenoviral vector Academic Article uri icon

Overview

MeSH Major

  • Adenoviruses, Human
  • Brain Neoplasms
  • Carcinoma
  • Defective Viruses
  • Genetic Therapy
  • Genetic Vectors
  • Glioblastoma
  • Membrane Glycoproteins
  • Peritoneal Neoplasms
  • Tumor Necrosis Factor-alpha

abstract

  • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a variety of transformed cell lines, but generally spares most normal cells. Transduction by an adenoviral vector expressing human TRAIL cDNA (Ad.TRAIL-GFP) resulted in both direct tumor cell killing as well as a potent bystander effect through presentation of TRAIL by transduced normal cells. Administration of Ad.TRAIL-GFP significantly prolonged survival of mice harboring either intracerebral glioblastomas or breast carcinoma-induced peritoneal carcinomatosis. Additionally, TRAIL induced prolonged transgene expression in normal tissue, presumably as a result of diminished immune-mediated destruction of vector-transduced cells. Taken together, these data suggest that vector-mediated transduction of TRAIL may represent an effective strategy for cancer gene therapy.

publication date

  • July 22, 2002

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1531709

Digital Object Identifier (DOI)

  • 10.1038/sj.neo.7900245

PubMed ID

  • 12082547

Additional Document Info

start page

  • 312

end page

  • 23

volume

  • 4

number

  • 4