Location, location, location: Embrane targeting directed by PX domains Review uri icon

Overview

MeSH Major

  • Intracellular Membranes
  • Phosphatidylinositols
  • Phosphoproteins

abstract

  • Phosphoinositide (PI)-binding domains play critical roles in the intracellular localization of a variety of cell-signaling proteins. The 120-amino acid Phox homology (PX) domain targets proteins to organelle membranes through interactions between two conserved basic motifs within the PX domain and specific PIs. The combination of protein-lipid and protein-protein interactions ensures the proper localization and regulation of PX domain-containing proteins. Upon proper localization, PX domain-containing proteins can then bind to additional proteins and execute their functions in a diverse set of biological pathways, including intracellular protein transport, cell growth and survival, cytoskeletal organization, and neutrophil defense.

publication date

  • November 30, 2001

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1065763

PubMed ID

  • 11729306

Additional Document Info

start page

  • 1881

end page

  • 5

volume

  • 294

number

  • 5548