Transforming growth factor-β1 stimulates L-arginine transport and metabolism in vascular smooth muscle cells: Role in polyamine and collagen synthesis Academic Article uri icon

Overview

MeSH Major

  • Arginine
  • Muscle, Smooth, Vascular
  • Transforming Growth Factor beta

abstract

  • These results demonstrate that TGF-beta(1) stimulates polyamine and L-proline synthesis by inducing the genes that regulate the transport and metabolism of L-arginine. In addition, they show that TGF-beta(1)-stimulated collagen production is dependent on L-proline formation. The ability of TGF-beta(1) to upregulate L-arginine transport and direct its metabolism to polyamines and L-proline may contribute to arterial remodeling at sites of vascular damage.

publication date

  • February 27, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 11222476

Additional Document Info

start page

  • 1121

end page

  • 7

volume

  • 103

number

  • 8