Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican population Academic Article uri icon


MeSH Major

  • Bipolar Disorder
  • Chromosome Mapping
  • Chromosomes, Human, Pair 18
  • Mood Disorders


  • We have searched for genes predisposing to bipolar disorder (BP) by studying individuals with the most extreme form of the affected phenotype, BP-I, ascertained from the genetically isolated population of the Central Valley of Costa Rica (CVCR). The results of a previous linkage analysis on two extended CVCR BP-I pedigrees, CR001 and CR004, and of linkage disequilibrium (LD) analyses of a CVCR population sample of BP-I patients implicated a candidate region on 18p11.3. We further investigated this region by creating a physical map and developing 4 new microsatellite and 26 single-nucleotide polymorphism markers for typing in the pedigree and population samples. We report the results of fine-scale association analyses in the population sample, as well as evaluation of haplotypes in pedigree CR001. Our results suggest a candidate region containing six genes but also highlight the complexities of LD mapping of common disorders.


publication date

  • September 25, 2001



  • Academic Article



  • eng

PubMed Central ID

  • PMC58756

Digital Object Identifier (DOI)

  • 10.1073/pnas.191519098

PubMed ID

  • 11572994

Additional Document Info

start page

  • 11485

end page

  • 90


  • 98


  • 20