Mechanoelectrical feedback: Role of β-adrenergic receptor activation in mediating load-dependent shortening of ventricular action potential and refractoriness Academic Article uri icon

Overview

MeSH Major

  • Action Potentials
  • Adrenergic beta-Antagonists
  • Heart Ventricles
  • Propranolol
  • Receptors, Adrenergic, beta

abstract

  • Increases in ventricular load mediate a decrease in ventricular APD and refractoriness through activation of the beta-adrenergic receptor. An increase in a cAMP-mediated K(+) current, possibly the slowly activating delayed rectifier I(Ks), may account in part for this form of mechanoelectrical coupling.

publication date

  • July 24, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 11468214

Additional Document Info

start page

  • 486

end page

  • 90

volume

  • 104

number

  • 4