Priming of memory but not effector CD8 T cells by a killed bacterial vaccine Academic Article uri icon

Overview

MeSH Major

  • Bacterial Vaccines
  • CD8-Positive T-Lymphocytes
  • Cytotoxicity, Immunologic
  • Immunologic Memory
  • Listeria monocytogenes
  • Listeriosis

abstract

  • Killed or inactivated vaccines targeting intracellular bacterial and protozoal pathogens are notoriously ineffective at generating protective immunity. For example, vaccination with heat-killed Listeria monocytogenes (HKLM) is not protective, although infection with live L. monocytogenes induces long-lived, CD8 T cell-mediated immunity. We demonstrate that HKLM immunization primes memory CD8 T lymphocyte populations that, although substantial in size, are ineffective at providing protection from subsequent L. monocytogenes infection. In contrast to live infection, which elicits large numbers of effector CD8 T cells, HKLM immunization primes T lymphocytes that do not acquire effector functions. Our studies show that it is possible to dissociate T cell-dependent protective immunity from memory T cell expansion, and that generation of effector T cells may be necessary for long-term protective immunity.

publication date

  • November 23, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1064571

PubMed ID

  • 11721060

Additional Document Info

start page

  • 1735

end page

  • 9

volume

  • 294

number

  • 5547