Allelic loss of 10q23, the PTEN tumour suppressor gene locus, in Barrett's oesophagus-associated adenocarcinoma Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Alleles
  • Barrett Esophagus
  • Chromosomes, Human, Pair 10
  • Genes, Tumor Suppressor
  • Phosphoric Monoester Hydrolases
  • Tumor Suppressor Proteins

abstract

  • PTEN is a putative tumour suppressor gene located on chromosome band 10q23. Mutations in PTEN have been identified in numerous human malignancies, including cancers of the brain, endometrium, ovary, and prostate. In this study, we screened 80 Barrett's oesophagus-associated adenocarcinomas (BOAd) for loss of heterozygosity (LOH) at 10q23, using the microsatellite markers D10S541, D10S219, and D10S551. Tumours demonstrating LOH were then screened for the presence or absence of PTEN mutations. LOH at one or more loci was identified in 17/80 (21%) cases. In none of these cases did we detect mutations in PTEN. The presence of LOH did not correlate with patient age, tumour stage, degree of differentiation, presence of perineural or vascular invasion, or overall survival. We conclude that LOH at chromosome 10q23 is uncommon in BOAd, is not associated with mutations in the PTEN tumour suppressor gene, and does not correlate with the clinical or pathologic features of these tumours. It is possible that PTEN is inactivated through other mechanisms in BOAd.

publication date

  • March 23, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2363812

Digital Object Identifier (DOI)

  • 10.1054/bjoc.2000.1660

PubMed ID

  • 11259087

Additional Document Info

start page

  • 748

end page

  • 53

volume

  • 84

number

  • 6