Coupling of the TCR to integrin activation by SLAP-130/Fyb Academic Article uri icon

Overview

MeSH Major

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Lymphocyte Function-Associated Antigen-1
  • Phosphoproteins
  • Receptors, Antigen, T-Cell
  • T-Lymphocytes

abstract

  • SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal, TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb-deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals.

publication date

  • September 21, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1063486

PubMed ID

  • 11567141

Additional Document Info

start page

  • 2263

end page

  • 5

volume

  • 293

number

  • 5538