Homocysteine impairs the nitric oxide synthase pathway role of asymmetric dimethylarginine Academic Article uri icon

Overview

MeSH Major

  • Amidohydrolases
  • Arginine
  • Endothelium, Vascular
  • Homocysteine
  • Nitric Oxide Synthase

abstract

  • Homocysteine post-translationally inhibits DDAH enzyme activity, causing ADMA to accumulate and inhibit nitric oxide synthesis. This may explain the known effect of homocysteine to impair endothelium-mediated nitric oxide-dependent vasodilatation.

publication date

  • November 20, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 11714652

Additional Document Info

start page

  • 2569

end page

  • 75

volume

  • 104

number

  • 21