Adjuvant radiotherapy for rectal cancer: A systematic overview of 8507 patients from 22 randomised trials Academic Article uri icon

Overview

MeSH Major

  • Endothelial Growth Factors
  • Fibroblasts
  • Genetic Vectors
  • Implants, Experimental
  • Lymphokines
  • Proto-Oncogene Proteins c-sis
  • Retroviridae
  • Skin
  • Transduction, Genetic
  • Wound Healing
  • Wounds and Injuries

abstract

  • Preoperative radiotherapy (at biologically effective doses >/=30 Gy) reduces risk of local recurrence and death from rectal cancer. If safety can be improved without compromising effectiveness, then overall survival would be moderately improved by use of preoperative radiotherapy, especially for young, high risk patients. Postoperative radiotherapy also reduces local recurrence, but short preoperative radiation schedules seem to be at least as effective as longer schedules.

authors

publication date

  • January 2001

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(01)06409-1

Additional Document Info

start page

  • 1291

end page

  • 304

volume

  • 358

number

  • 9290