Adjuvant radiotherapy for rectal cancer: A systematic overview of 8507 patients from 22 randomised trials
Endothelial Growth Factors
Proto-Oncogene Proteins c-sis
Wounds and Injuries
Preoperative radiotherapy (at biologically effective doses >/=30 Gy) reduces risk of local recurrence and death from rectal cancer. If safety can be improved without compromising effectiveness, then overall survival would be moderately improved by use of preoperative radiotherapy, especially for young, high risk patients. Postoperative radiotherapy also reduces local recurrence, but short preoperative radiation schedules seem to be at least as effective as longer schedules.