Long-term impact of smoking on lung epithelial proliferation in current and former smokers Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Epithelial Cells
  • Lung
  • Smoking
  • Smoking Cessation

abstract

  • Smoking appears to elicit a dose-related proliferative response in the bronchial epithelia of active smokers. Although the proliferative response decreased gradually in former smokers, a subset of individuals had detectable proliferation for many years and may benefit from targeted chemoprevention. Bronchial epithelial proliferation, measured by Ki-67, may provide a useful biomarker in the assessment of lung cancer risk and in the response to chemopreventive interventions.

publication date

  • July 18, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 11459869

Additional Document Info

start page

  • 1081

end page

  • 8

volume

  • 93

number

  • 14