Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy Academic Article uri icon

Overview

MeSH Major

  • Cardiomegaly
  • Cardiomyopathy, Hypertrophic
  • Endomyocardial Fibrosis
  • Hypolipidemic Agents
  • Simvastatin

abstract

  • Simvastatin induced the regression of hypertrophy and fibrosis, improved cardiac function, and reduced ERK1/2 activity in the beta-myosin heavy chain-Q(403) rabbits. These findings highlight the need for clinical trials to determine the effects of simvastatin on cardiac hypertrophy, fibrosis, and dysfunction in humans with hypertrophic cardiomyopathy and heart failure.

publication date

  • July 17, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2768618

PubMed ID

  • 11457751

Additional Document Info

start page

  • 317

end page

  • 24

volume

  • 104

number

  • 3