Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation Academic Article uri icon


MeSH Major

  • Hippocampus
  • Long-Term Potentiation
  • Neurons
  • Receptors, AMPA
  • Synapses
  • Synaptic Transmission
  • Synaptophysin


  • A change in the efficiency of synaptic communication between neurons is thought to underlie learning. Consistent with recent studies of such changes, we find that long-lasting potentiation of synaptic transmission between cultured hippocampal neurons is accompanied by an increase in the number of clusters of postsynaptic glutamate receptors containing the subunit GluR1. In addition, potentiation is accompanied by a rapid and long-lasting increase in the number of clusters of the presynaptic protein synaptophysin and the number of sites at which synaptophysin and GluR1 are colocalized. These results suggest that potentiation involves rapid coordinate changes in the distribution of proteins in the presynaptic neuron as well as the postsynaptic neuron.

publication date

  • November 16, 2001



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1066273

PubMed ID

  • 11641465

Additional Document Info

start page

  • 1547

end page

  • 50


  • 294


  • 5546