Tumor therapy with targeted atomic nanogenerators Academic Article uri icon

Overview

MeSH Major

  • Actinium
  • Immunoconjugates
  • Neoplasms
  • Radioimmunotherapy

abstract

  • A single, high linear energy transfer alpha particle can kill a target cell. We have developed methods to target molecular-sized generators of alpha-emitting isotope cascades to the inside of cancer cells using actinium-225 coupled to internalizing monoclonal antibodies. In vitro, these constructs specifically killed leukemia, lymphoma, breast, ovarian, neuroblastoma, and prostate cancer cells at becquerel (picocurie) levels. Injection of single doses of the constructs at kilobecquerel (nanocurie) levels into mice bearing solid prostate carcinoma or disseminated human lymphoma induced tumor regression and prolonged survival, without toxicity, in a substantial fraction of animals. Nanogenerators targeting a wide variety of cancers may be possible.

publication date

  • November 16, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1064126

PubMed ID

  • 11711678

Additional Document Info

start page

  • 1537

end page

  • 40

volume

  • 294

number

  • 5546