Improved in vivo pancreatic islet function after prolonged in vitro islet culture Academic Article uri icon

Overview

MeSH Major

  • Culture Techniques
  • Islets of Langerhans
  • Islets of Langerhans Transplantation
  • Transplantation, Heterologous

abstract

  • These data demonstrate that prolonged islet culture in M-SFM sustained viability and function, and in some instances had a positive effect on in vivo islet function, particularly in the 1-month cultures. No negative effect on long-term in vivo function was demonstrated in this study. Confirmation in clinical models utilizing extended (1-2 months) islet culture in M-SFM could significantly enhance islet transplantation by allowing the identification of best-matched recipients, pretransplantation recipient conditioning, and possible pretransplantation islet modifications to promote engraftment and prolonged graft function.

publication date

  • December 15, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 11740381

Additional Document Info

start page

  • 1730

end page

  • 6

volume

  • 72

number

  • 11