Nonproliferating bystander CD4+ T cells lacking activation markers support HIV replication during immune activation Academic Article uri icon

Overview

MeSH Major

  • Bacterial Toxins
  • CD4-Positive T-Lymphocytes
  • HIV-1
  • Lymphocyte Activation
  • T-Lymphocyte Subsets
  • Virus Replication

abstract

  • HIV replicates primarily in lymphoid tissue and immune activation is a major stimulus in vivo. To determine the cells responsible for HIV replication during Ag-driven T cell activation, we used a novel in vitro model employing dendritic cell presentation of superantigen to CD4(+) T cells. Dendritic cells and CD4(+) T cells are the major constituents of the paracortical region of lymphoid organs, the main site of Ag-specific activation and HIV replication. Unexpectedly, replication occurred in nonproliferating bystander CD4(+) T cells that lacked activation markers. In contrast, activated Ag-specific cells were relatively protected from infection, which was associated with CCR5 and CXC chemokine receptor 4 down-regulation. The finding that HIV replication is not restricted to highly activated Ag-specific CD4(+) T cells has implications for therapy, efforts to eradicate viral reservoirs, immune control of HIV, and Ag-specific immune defects.

publication date

  • May 15, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.166.10.6437

PubMed ID

  • 11342670

Additional Document Info

start page

  • 6437

end page

  • 43

volume

  • 166

number

  • 10