Nonlinear-dynamical arrhythmia control in humans Academic Article uri icon


MeSH Major

  • Arrhythmias, Cardiac
  • Atrioventricular Node


  • Nonlinear-dynamical control techniques, also known as chaos control, have been used with great success to control a wide range of physical systems. Such techniques have been used to control the behavior of in vitro excitable biological tissue, suggesting their potential for clinical utility. However, the feasibility of using such techniques to control physiological processes has not been demonstrated in humans. Here we show that nonlinear-dynamical control can modulate human cardiac electrophysiological dynamics by rapidly stabilizing an unstable target rhythm. Specifically, in 52/54 control attempts in five patients, we successfully terminated pacing-induced period-2 atrioventricular-nodal conduction alternans by stabilizing the underlying unstable steady-state conduction. This proof-of-concept demonstration shows that nonlinear-dynamical control techniques are clinically feasible and provides a foundation for developing such techniques for more complex forms of clinical arrhythmia.

publication date

  • May 8, 2001



  • Academic Article



  • eng

PubMed Central ID

  • PMC33298

Digital Object Identifier (DOI)

  • 10.1073/pnas.091553398

PubMed ID

  • 11320216

Additional Document Info

start page

  • 5827

end page

  • 32


  • 98


  • 10