Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy Academic Article Article uri icon

Overview

MeSH Major

  • Chromosomes, Human, Pair 7
  • Gene Deletion
  • Immunoglobulin G
  • Lymphoma, B-Cell, Marginal Zone
  • Splenic Neoplasms
  • Translocation, Genetic

abstract

  • 20-30% of gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with Helicobacter pylori do not regress after antibiotic therapy. Regression can be assessed only by extended follow-up. To assess whether t(11;18, q21;q21), which results in a chimeric transcript between the AP12 and MLT genes, predicts lymphoma resistance to antibiotic therapy, we screened for the fusion transcript with RT-PCR in ten responsive and 12 non-responsive gastric MALT lymphomas. The AP12-MLT transcript was detected in nine (75%) of 12 patients non-responsive to antibiotic therapy but not in responsive patients. Most H pylori-associated gastric MALT lymphomas that do not respond to antibiotic therapy are associated with t(11;18, q21;q21).

publication date

  • January 6, 2001

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(00)03571-6

PubMed ID

  • 11197361

Additional Document Info

start page

  • 39

end page

  • 40

volume

  • 357

number

  • 9249