Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome Academic Article uri icon

Overview

MeSH Major

  • Blast Crisis
  • Enzyme Inhibitors
  • Fusion Proteins, bcr-abl
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Piperazines
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Protein-Tyrosine Kinases
  • Pyrimidines

abstract

  • The BCR-ABL tyrosine kinase inhibitor STI571 is well tolerated and has substantial activity in the blast crises of CML and in Ph-positive ALL.

publication date

  • April 5, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1056/NEJM200104053441402

PubMed ID

  • 11287973

Additional Document Info

start page

  • 1038

end page

  • 42

volume

  • 344

number

  • 14