Electrophysiologic effects of a novel selective adenosine A1 agonist (CVT-510) on atrioventricular nodal conduction in humans Academic Article uri icon

Overview

MeSH Major

  • Adenosine
  • Atrioventricular Node
  • Furans
  • Purinergic P1 Receptor Agonists

abstract

  • CVT-510 promptly prolongs AV nodal conduction and does not affect sinus rate or blood pressure. Selective stimulation of the A(1)-adenosine receptor by CVT-510 may be useful for immediate control of heart rate in atrial fibrillation/flutter and to convert paroxysmal supraventricular tachycardia to sinus rhythm, while avoiding vasodilatation mediated by the A(2)-adenosine receptor, as well as the vasodepressor and negative inotropic effects associated with beta-adrenergic receptor blockade and/or calcium channel blockers.

publication date

  • December 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 11584330

Additional Document Info

start page

  • 237

end page

  • 45

volume

  • 6

number

  • 3