Renal cell apoptosis in chronic obstructive uropathy: The roles of caspases Academic Article uri icon

Overview

MeSH Major

  • Apoptosis
  • Caspases
  • Kidney Tubules
  • Ureteral Obstruction

abstract

  • Urinary obstruction in mice induces apoptosis of both tubular and interstitial cells in the affected kidney in a distinctive pattern that parallels an increased expression of caspases. This correlation suggests that these caspases mediate COU-associated renal cell apoptosis. Among the evaluated caspases, increased renal caspase 3 activity implies its central role in renal cell apoptosis associated with urinary obstruction.

publication date

  • January 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1046/j.1523-1755.2001.060003924.x

PubMed ID

  • 11532087

Additional Document Info

start page

  • 924

end page

  • 34

volume

  • 60

number

  • 3