Potential role of recombinant annexin II in diabetic vascular injury Academic Article uri icon

Overview

MeSH Major

  • Annexin A2
  • Diabetic Angiopathies
  • Endothelium, Vascular

abstract

  • Hyperinsulinemia and hyperglycemia have been associated with vascular injury such as atherosclerosis in diabetes mellitus. Recently, annexin II, a member of annexin family proteins, has been found to work as co-receptor on endothelial cells for plasminogen and tissue plasminogen activator, facilitating plasmin generation on the surface of vascular endothelium. In this review, we overviewed the effect of glucose and insulin on plasmin generation in endothelial cells and its potential modulation by recombinant annexin II (rAN II) based on our data.

publication date

  • December 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 11795280

Additional Document Info

start page

  • 308

end page

  • 11

volume

  • 947