Inhibition of cyclooxygenase-2: An approach to preventing cancer of the upper aerodigestive tract Review uri icon

Overview

MeSH Major

  • Anticarcinogenic Agents
  • Cyclooxygenase Inhibitors
  • Esophageal Neoplasms
  • Isoenzymes
  • Respiratory Tract Neoplasms

abstract

  • Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2), an inducible form of COX, represents a potential pharmacologic target to prevent cancer. Key data suggesting a causal relationship between increased COX-2 activity and carcinogenesis and possible mechanisms of action of COX-2 in this context will be discussed. The possibility that COX-2 represents a pharmacological target for preventing upper aerodigestive cancers (head and neck, lung) will be emphasized. Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors.

publication date

  • December 2001

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 11795429

Additional Document Info

start page

  • 109

end page

  • 15

volume

  • 952