Anagrelide metabolite induces thrombocytopenia in mice by inhibiting megakaryocyte maturation without inducing platelet aggregation Academic Article Article uri icon

Overview

MeSH Major

  • Angiogenesis Inhibitors
  • Endothelium, Vascular
  • Growth Substances
  • Neoplasms

abstract

  • We describe a cross-species reactive anagrelide metabolite that selectively inhibits MK maturation and migration, lowering platelet levels without influencing platelet aggregation.

publication date

  • December 2001

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0301-472X(01)00742-1

PubMed ID

  • 11750100

Additional Document Info

start page

  • 1417

end page

  • 24

volume

  • 29

number

  • 12