Intra-arterial thrombin injection of an ascending aortic pseudoaneurysm complicated by transient ischemic attack and rescued with systemic abciximab Academic Article uri icon


MeSH Major

  • Aneurysm, False
  • Aneurysm, Infected
  • Antibodies, Monoclonal
  • Aortic Aneurysm, Thoracic
  • Hemostatics
  • Immunoglobulin Fab Fragments
  • Ischemic Attack, Transient
  • Platelet Aggregation Inhibitors
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Thrombin


  • Thrombin injection as a means of inducing thrombus formation has recently received wide attention as an alternative treatment for pseudoaneurysm. We present a case of a 67-year-old man in whom a large mycotic pseudoaneurysm developed in the ascending aorta because of sternal osteomyelitis and mediastinitis after coronary artery bypass grafting. Transcatheter intra-arterial thrombin injection was performed, and it successfully induced pseudoaneurysm thrombosis. However, the procedure was complicated by a sudden transient ischemic attack caused by thrombus propagation into the cerebral circulation. Complete thrombus dissolution in the cerebral circulation with the resolution of neurologic symptoms was achieved by means of intravenous abciximab.

publication date

  • November 2001



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1067/mva.2001.116968

PubMed ID

  • 11700498

Additional Document Info

start page

  • 939

end page

  • 42


  • 34


  • 5