Induction chemotherapy plus three-dimensional conformal radiation therapy in the definitive treatment of locally advanced non-small-cell lung cancer Academic Article Article uri icon


MeSH Major

  • Carcinoma, Squamous Cell
  • Combined Modality Therapy
  • Head and Neck Neoplasms
  • Maximum Tolerated Dose


  • Despite more Stage IIIB patients in the combined-modality group, the addition of chemotherapy to 3D-CRT produced a survival advantage over 3D-CRT alone in Stage III NSCLC without a concomitant increase in toxicity. Chemotherapy thus appears to be beneficial, even in patients who are receiving higher doses of radiation therapy than are typically given with conventional techniques. Because locoregional failure remains a major challenge in patients with advanced disease, 3D-CRT in conjunction with chemotherapy may allow safe treatment to the dose levels required to further enhance local control.

publication date

  • November 2001



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/S0360-3016(01)01666-2

PubMed ID

  • 11597806

Additional Document Info

start page

  • 660

end page

  • 5


  • 51


  • 3