Malignant transformation of the esophageal mucosa is enhanced in p27 knockout mice
Cell Cycle Proteins
Cell Transformation, Neoplastic
Genes, Tumor Suppressor
Tumor Suppressor Proteins
This experimental mouse model of Barrett esophagus and Barrett- associated adenocarcinoma is similar to what occurs in human beings and may be useful in developing methods to inhibit malignant transformation of Barrett esophagus.