Cyclo-oxygenase 2: A pharmacological target for the prevention of cancer Article Report uri icon


MeSH Major

  • Antineoplastic Agents
  • Breast Neoplasms
  • Models, Theoretical
  • Neutropenia


  • Understanding the mechanisms underlying carcinogenesis provides insights that are necessary for the development of therapeutic strategies to prevent cancer. Chemoprevention--the use of drugs or natural substances to inhibit carcinogenesis - is an important and rapidly evolving aspect of cancer research. We discuss evidence that cyclooxygenase 2 (COX 2), an inducible form of the enzyme, is a potential pharmacological target to prevent cancer. Key data implicating a causal relation between increased activity of COX 2 and carcinogenesis and possible mechanisms of action of COX 2 in this context are covered. Importantly, selective COX 2 inhibitors appear to be safe enough in human beings to allow large-scale clinical testing in healthy people. Several chemoprevention trials using selective COX 2 inhibitors are underway.

publication date

  • September 2001



  • Report


Digital Object Identifier (DOI)

  • 10.1016/S1470-2045(01)00488-0

PubMed ID

  • 11905709

Additional Document Info

start page

  • 544

end page

  • 51


  • 2


  • 9