Peritoneal implantation of macroencapsulated porcine pancreatic islets in diabetic rats ameliorates severe hyperglycemia and prevents retraction and simplification of hippocampal dendrites Academic Article Article uri icon


MeSH Major

  • Carcinoma, Renal Cell
  • Cell Culture Techniques
  • Kidney Neoplasms


  • The hippocampus of rats with uncontrolled insulin-dependent diabetes undergoes retraction and simplification of apical dendrites of the CA3 pyramidal neurons and synaptic rearrangements within mossy fiber terminals that could alter hippocampal connectivity and function. The intraperitoneal implantation of hydrophilic agarose macrobeads containing porcine islets for 17 days in rats with streptozotocin-induced diabetes results in normalization of body weight gain, significant control of hyperglycemia and prevention of hippocampal dendritic remodeling, and therefore, provides an effective therapeutic option.

publication date

  • June 2001



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/S0006-8993(01)02400-3

PubMed ID

  • 11384623

Additional Document Info

start page

  • 282

end page

  • 7


  • 902


  • 2