Compartmentalization of vascular endothelial growth factor to the epithelial surface of the human lung Academic Article uri icon

Overview

MeSH Major

  • Endothelial Growth Factors
  • Epithelial Cells
  • Lung
  • Lymphokines

abstract

  • With the knowledge that proteins of molecular mass like VEGF (34 to 46 kDa) slowly diffuse across the alveolar epithelium, it is likely that this high level "reservoir" of VEGF protein on the respiratory epithelial surface plays a role in normal lung endothelial biology. However, this compartmentalized VEGF reservoir may also be a "Damocles sword" poised to induce lung endothelial permeability in conditions of acute lung injury when the integrity of the alveolar epithelial barrier is breached.

publication date

  • December 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1950032

PubMed ID

  • 11471568

Additional Document Info

start page

  • 240

end page

  • 6

volume

  • 7

number

  • 4