Transnasal and transsphenoidal MRI-guided biopsies of petroclival tumors Academic Article Article uri icon


MeSH Major

  • Cell Transformation, Viral
  • Oncogenes
  • Receptors, Cell Surface


  • Magnetic resonance imaging (MRI) allows excellent tissue characterization in the area of the petroclival region and can depict lesions not visualized with ultrasound or computed tomography (CT). The aim of this study was to demonstrate the clinical feasibility and utility of an interactive MR-guidance system to target and biopsy tumors in the petroclival region, MRI-guided biopsies of 10 patients with tumors in the clivus and petrous apex were performed in an open 0.5-T MR system. Lesions were targeted through a transsphenoidal or transnasal approach. Imaging during biopsies was achieved by a combination of standard and interactive mode. T1-weighted spin-echo, T2-weighted fast spin-echo (FSE), and three-dimensional T1-weighted gradient-echo (GRE) scans (standard mode) were selected to provide optimal tissue characterization for both the lesion and surrounding structures and varied according to the anatomic site. For interactive imaging, T1-weighted GRE and T2-weighted FSE sequences were used. We performed MRI-guided transsphenoidal biopsies in 10 patients who had lesions identified by CT (n = 5) and/or (n = 10). The indications for biopsies were to differentiate between suspected malignant processes (n = 4) and benign processes (n = 6). Lesions adjacent to structures like the internal carotid artery were accurately targeted in particular. All biopsies were performed successfully and were the basis for selection of further treatment. No complications occurred during the procedures. An open MR system allows interactive control of biopsies in the area of the petroclival region, providing maximum patient safety and diagnostic accuracy not possible in other systems. The advantages of MRI tissue characterization are combined with an interactive, one-step method of localization and targeting, as well as tissue sampling. © 2001 Wiley-Liss, Inc.

publication date

  • January 20, 2001



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1522-2586(200101)13:1<3::AID-JMRI1001>3.0.CO;2-P

PubMed ID

  • 11169796

Additional Document Info

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