Activation of STAT proteins and growth control Article Report uri icon

Overview

MeSH Major

  • Fungal Proteins
  • Gene Products, tat

abstract

  • This review will discuss how STAT (Signal Transducers and Activators of Transcription) proteins, a group of transcription factors that transmit signals from the extracellular surface of cells to the nucleus, are involved in growth control. I will discuss the anatomy of a STAT protein, how it works as a transcription factor, the molecules that regulate its "activity", the phenotypes of mice that lack individual STAT proteins and their involvement in growth, differentiation, apoptosis, and transformation. Finally, a number of examples will be presented of how dysregulated STAT signaling may be involved in the pathogenesis of cancer.

publication date

  • February 15, 2001

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.1002/1521-1878(200102)23:2<161::AID-BIES1023>3.0.CO;2-0

PubMed ID

  • 11169589

Additional Document Info

start page

  • 161

end page

  • 9

volume

  • 23

number

  • 2