Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double-blind, multicenter study. Academic Article Article uri icon

Overview

MeSH

  • Adult
  • Aged
  • Aged, 80 and over
  • Aztreonam
  • Double-Blind Method
  • Drug Resistance, Microbial
  • Drug Therapy, Combination
  • Gram-Positive Bacteria
  • Hospitalization
  • Humans
  • Linezolid
  • Male
  • Middle Aged
  • Monobactams
  • Safety
  • Time Factors
  • Treatment Outcome

MeSH Major

  • Acetamides
  • Anti-Bacterial Agents
  • Cross Infection
  • Oxazolidinones
  • Pneumonia
  • Vancomycin

abstract

  • Linezolid, the first oxazolidinone, is active against gram-positive bacteria, including multidrug-resistant strains. This multinational, randomized, double-blind, controlled trial compared the efficacy, safety, and tolerability of linezolid with vancomycin in the treatment of nosocomial pneumonia. A total of 203 patients received intravenous linezolid, 600 mg twice daily, plus aztreonam, and 193 patients received vancomycin, 1 g intravenously twice daily, plus aztreonam for 7-21 days. Clinical and microbiological outcomes were evaluated at test of cure 12-28 days after treatment. Clinical cure rates (71 [66.4%] of 107 for linezolid vs. 62 [68.1%] of 91 for vancomycin) and microbiological success rates (36 [67.9%] of 53 vs. 28 [71.8%] of 39, respectively) for evaluable patients were equivalent between treatment groups. Eradication rates of methicillin-resistant Staphylococcus aureus and safety evaluations were similar between treatment groups. Resistance to either treatment was not detected. Linezolid is a well-tolerated, effective treatment for adults with gram-positive nosocomial pneumonia.

authors

publication date

  • February 1, 2001

has subject area

  • Acetamides
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents
  • Aztreonam
  • Cross Infection
  • Double-Blind Method
  • Drug Resistance, Microbial
  • Drug Therapy, Combination
  • Gram-Positive Bacteria
  • Hospitalization
  • Humans
  • Linezolid
  • Male
  • Middle Aged
  • Monobactams
  • Oxazolidinones
  • Pneumonia
  • Safety
  • Time Factors
  • Treatment Outcome
  • Vancomycin

Research

keywords

  • Clinical Trial
  • Comparative Study
  • Journal Article
  • Multicenter Study
  • Randomized Controlled Trial

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1086/318486

PubMed ID

  • 11170948

Additional Document Info

start page

  • 402

end page

  • 412

volume

  • 32

number

  • 3