Renal angiomyolipoma: Further immunophenotypic characterization of an expanding morphologic spectrum Academic Article uri icon

Overview

MeSH Major

  • Angiomyolipoma
  • Kidney Neoplasms

abstract

  • In renal angiomyolipoma, the epithelioid and spindle cells have preferential staining patterns for melanoma-associated antigens versus smooth muscle antigens, respectively. Positivity in renal angiomyolipoma for HMB-50, NKI/C3, and tyrosinase, in addition to HMB-45, provides evidence for the presence of different melanoma-associated gene products. Immunophenotypic overlap of the 3 histologically distinct renal angiomyolipoma cell populations suggests a common cell line, supporting a unitarian concept for renal angiomyolipoma. Ultrastructural characteristics of the 3 renal angiomyolipoma cell phenotypes parallel the immunophenotype, giving further support to a common cell line. Our study lends further credence to the perivascular epithelioid cell concept as proposed by Bonetti and colleagues.

publication date

  • June 21, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 11371226

Additional Document Info

start page

  • 751

end page

  • 8

volume

  • 125

number

  • 6