Resistance to multiple steroids in two sisters Article Conference Paper uri icon

Overview

MeSH Major

  • Adaptation, Psychological
  • Adolescent Behavior
  • Affect
  • Child Behavior
  • HIV Seropositivity
  • Hemophilia A

abstract

  • A 14-year-old Native American girl from the Iroquois Nation was referred as a potential patient with the syndrome of Apparent Mineralocorticoid Excess. Instead, her evaluation revealed resistance to glucocorticoids, mineralocorticoids, and androgens. She lacked Cushingoid features in spite of significantly high cortisol levels. Menstruation was regular and there was no clinical evidence of masculinization despite high serum androgen levels in the male range. The patient's sister had similar clinical features. Partial resistance to exogenous glucocorticoid and mineralocorticoid administration was well demonstrated in both patients. It is proposed that these patients represent the first cases of partial resistance to multiple steroids, possibly owing to a coactivator defect.

publication date

  • June 18, 2001

Research

keywords

  • Conference Paper

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0960-0760(01)00045-0

PubMed ID

  • 11384874

Additional Document Info

start page

  • 161

end page

  • 6

volume

  • 76

number

  • 1-5