Interleukin-1 receptor antagonist gene polymorphism and circulating levels of human immunodeficiency virus type 1 RNA in Brazilian women Academic Article uri icon

Overview

MeSH Major

  • HIV Seropositivity
  • HIV-1
  • Polymorphism, Genetic
  • RNA, Viral
  • Sialoglycoproteins

abstract

  • Interleukin-1 receptor antagonist (IL-1ra) gene polymorphisms in 83 human immunodeficiency virus (HIV)-seropositive women were evaluated. Fourteen of the subjects (16.9%) were homozygous for IL-1ra allele 2 (IL-1RN*2). These women had a lower median level of HIV RNA than did women homozygous for allele 1 (IL-1RN*1) (P = 0.01) or heterozygous for both alleles (P = 0.04). Among 46 subjects not receiving antiretroviral treatment, HIV levels were also reduced in IL-1RN*2 homozygous individuals (P < 0.05). There was no relation between IL-1ra alleles and CD4 levels.

publication date

  • July 3, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC114344

Digital Object Identifier (DOI)

  • 10.1128/JVI.75.13.6242-6244.2001

PubMed ID

  • 11390630

Additional Document Info

start page

  • 6242

end page

  • 4

volume

  • 75

number

  • 13