Increased vasopressin and adrenocorticotropin responses to stress in the midluteal phase of the menstrual cycle. Academic Article uri icon

Overview

MeSH

  • Adult
  • Blood Glucose
  • Exercise
  • Female
  • Humans

MeSH Major

  • Adrenocorticotropic Hormone
  • Luteal Phase
  • Stress, Physiological
  • Vasopressins

abstract

  • Accumulating evidence indicates that gonadal steroids modulate functioning of the hypothalamic-pituitary-adrenal (HPA) axis, which has been closely linked to the pathophysiology of anxiety and depression. However, the effect of the natural menstrual cycle on HPA axis responsivity to stress has not been clearly described. In nine healthy women, metabolic and hormonal responses to treadmill exercise stress during the early follicular phase of the menstrual cycle, when gonadal steroid levels are low, were compared with responses in the midluteal phase of the cycle, when both progesterone and estrogen levels are relatively high. Exercise intensity was gradually increased over 20 min to reach 90% of each subject's maximal oxygen consumption during the final 5 min of exercise. Basal plasma lactate, glucose, ACTH, vasopressin, oxytocin, and cortisol levels were similar in the two cycle phases. However, in response to exercise stress, women in the midluteal phase had enhanced ACTH (P < 0.0001), vasopressin (P < 0.01), and glucose (P < 0.001) secretion. These findings suggest that relatively low levels of gonadal steroids during the early follicular phase of the menstrual cycle provide protection from the impact of stress on the HPA axis.

publication date

  • June 2001

has subject area

  • Adrenocorticotropic Hormone
  • Adult
  • Blood Glucose
  • Exercise
  • Female
  • Humans
  • Luteal Phase
  • Stress, Physiological
  • Vasopressins

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1210/jcem.86.6.7596

PubMed ID

  • 11397850

Additional Document Info

start page

  • 2525

end page

  • 2530

volume

  • 86

number

  • 6