Alloimmune thrombocytopenia in the fetus and newborn Review uri icon


MeSH Major

  • Thrombocytopenia


  • Alloimmune thrombocytopenia is an interesting and challenging disease. Identification in the fetus and newborn by screening remains to be clarified. The primary clinical criterion for neonatal diagnosis appears to be a neonatal platelet count of <50 x 10(9)/L. Treatment of the neonate can be accomplished with intravenous immunoglobulin (IVIG) +/- steroids or with matched platelet transfusion. Cranial ultrasonography is important. Testing can be performed on the parents and requires a highly experienced laboratory. If an affected fetus is identified, based on a previous affected neonate and a homozygous father, antenatal management is needed. Studies have been completed that inform the still controversial decision. IVIG remains the basis of therapy but appears to require a higher dose (2 g/kg/week) and/or the addition of 1 mg/kg of prednisone in the highest risk cases, those with antenatal intracranial hemorrhage.

publication date

  • June 30, 2001



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.1055/s-2001-15254

PubMed ID

  • 11446658

Additional Document Info

start page

  • 245

end page

  • 52


  • 27


  • 3