Modulation of red cell mass by neocytolysis in space and on earth Review uri icon

Overview

MeSH Major

  • Anemia, Hemolytic
  • Erythrocyte Volume
  • Space Flight

abstract

  • Astronauts predictably experience anemia after return from space. Upon entering microgravity, the blood volume in the extremities pools centrally and plasma volume decreases, causing plethora and erythropoietin suppression. There ensues neocytolysis, selective hemolysis of the youngest circulating red cells, allowing rapid adaptation to the space environment but becoming maladaptive on re-entry to a gravitational field. The existence of this physiologic control process was confirmed in polycythemic high-altitude dwellers transported to sea level. Pathologic neocytolysis contributes to the anemia of renal failure. Understanding the process has implications for optimizing erythropoietin-dosing schedules and the therapy of other human disorders. Human and rodent models of neocytolysis are being created to help find out how interactions between endothelial cells, reticuloendothelial phagocytes and young erythrocytes are altered, and to shed light on the expression of surface adhesion molecules underlying this process. Thus, unraveling a problem for space travelers has uncovered a physiologic process controlling the red cell mass that can be applied to human disorders on Earth.

publication date

  • July 4, 2001

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 11200988

Additional Document Info

start page

  • R91

end page

  • 4

volume

  • 441

number

  • 2-3 SUPPL.