Cyclooxygenase-2: A target for the prevention and treatment of breast cancer Article Conference Paper uri icon

Overview

MeSH Major

  • Coronary Artery Disease
  • Nicotine
  • Smoking

abstract

  • Cyclooxygenase-2 (COX-2), an inducible prostaglandin synthase, is normally expressed in parts of the kidney and brain. Aberrant COX-2 expression was first reported in colorectal carcinomas and adenomas, and has now been detected in various human cancers, including those of the breast. Strikingly, COX-2 overexpression in murine mammary gland is sufficient to cause tumour formation. To date, the role of COX-2 in tumorigenesis has been most intensively studied in the colon. Thus, the relationship between COX-2 and neoplasia can best be illustrated with reference to intestinal tumorigenesis. Here we consider the potential utility of selective COX-2 inhibitors for the prevention and treatment of breast cancer. Data for cancers of the colon and breast are compared where possible. In addition, the mechanisms by which COX-2 is upregulated in cancers and contributes to tumorigenesis are discussed. Importantly, several recent studies of mammary tumorigenesis in animal models have found selective COX-2 inhibitors to be effective in the prevention and treatment of breast cancer. Clinical trials will be needed to determine whether COX-2 inhibition represents a useful approach to preventing or treating human breast cancer.

publication date

  • July 24, 2001

Research

keywords

  • Conference Paper

Identity

Digital Object Identifier (DOI)

  • 10.1677/erc.0.0080097

PubMed ID

  • 11397667

Additional Document Info

start page

  • 97

end page

  • 114

volume

  • 8

number

  • 2