Cyclooxygenase-2 inhibitor NS-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity Academic Article uri icon

Overview

MeSH Major

  • Cyclooxygenase Inhibitors
  • Isoenzymes
  • Lipopolysaccharides
  • Neurons
  • Nitrobenzenes
  • Sulfonamides

abstract

  • COX-2, in part through TNF-alpha-related mechanisms, contributes to LPS-induced neuronal death. The data support the hypothesis that COX-2, in addition to its role in glutamate excitotoxicity, participates in the cytotoxicity associated with inflammation.

publication date

  • October 22, 2001

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 11588328

Additional Document Info

start page

  • 2370

end page

  • 5

volume

  • 32

number

  • 10