Chronic unloading by left ventricular assist device reverses contractile dysfunction and alters gene expression in end-stage heart failure Academic Article uri icon

Overview

MeSH Major

  • Heart Failure
  • Heart-Assist Devices
  • Myocardial Contraction

abstract

  • LVAD support can improve contractile strength of intact myocardium and reverse the negative FFR associated with end-stage heart failure. The expression of genes encoding for proteins involved in Ca(2+) cycling is upregulated (reverse molecular remodeling), but only the protein content of SERCA2a is increased.

publication date

  • November 28, 2000

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 11094037

Additional Document Info

start page

  • 2713

end page

  • 9

volume

  • 102

number

  • 22