Evidence for genetic linkage Alzheimer's disease to chromosome 10q Academic Article uri icon

Overview

MeSH Major

  • Alzheimer Disease
  • Chromosomes, Human, Pair 10
  • Genetic Linkage
  • Insulysin

abstract

  • Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades Abeta, the principal component of beta-amyloid and one of the neuropathological hallmarks of Alzheimer's disease (AD). We performed parametric and nonparametric linkage analyses of seven genetic markers on chromosome 10q, six of which map near the IDE gene, in 435 multiplex AD families. These analyses revealed significant evidence of linkage for adjacent markers (D10S1671, D10S583, D10S1710, and D10S566), which was most pronounced in late-onset families. Furthermore, we found evidence for allele-specific association between the putative disease locus and marker D10S583, which has recently been located within 195 kilobases of the IDE gene.

publication date

  • December 22, 2000

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.290.5500.2302

PubMed ID

  • 11125142

Additional Document Info

start page

  • 2302

end page

  • 3

volume

  • 290

number

  • 5500